Senior Citizen News Article
Heart Association Says Use Pain Killers With Fewest Risks
New advisory on taking COX-2 inhibitors and non-steroidal anti-inflammatory drugs by American Heart Association
March 25, 2005 - Confused about which painkillers are safe to use? A new American Heart Association science advisory on the use of COX-2 inhibitors and other non-steroidal anti-inflammatory drugs (NSAIDS) suggests this simple rule of thumb: Use the drug with the fewest known risks.
The advisory affirms the cautions issued by the U.S. Food and Drug Administration (FDA) in February 2005.
This rule means that potent drugs like the COX-2 inhibitors Celebrex (celecoxib) and Bextra (valdecoxib) should be “held in reserve, generally for short-term use,” said Joel S. Bennett, M.D., a hematologist and a member of the writing group that drafted the advisory.
The association advisory comes in response to several reports that COX-2 inhibitors increase cardiovascular risks and is published in Circulation: Journal of the American Heart Association
Bennett, who is a professor of medicine at the University of Pennsylvania, explained that COX-2 drugs were developed with the idea of “having a good pain reliever that wouldn’t upset the stomach, which sounded great.” But that good idea was questioned when reports surfaced that long-term use of one of the drugs, rofecoxib (Vioxx), was associated with increased heart attacks and strokes.
Merck, the company that makes Vioxx, voluntarily removed it from the market in September 2004 when it received evidence that daily use of the drug for more than 18 months increased the risk of blood clots. Since then, the FDA has conducted hearings into other COX-2 inhibitors.
The American Heart Association advisory recommends physicians weigh the benefits and risks before prescribing Celebrex or Bextra. Because the risks of adverse effects of COX-2 inhibitors are likely greatest in patients with – or at high risk for – cardiovascular disease, the statement suggests limiting the use of COX-2 drugs to those who have no appropriate alternatives. The lowest recommended dose should be given for the shortest duration necessary.
The advisory also addresses the use of other popular pain relievers such as aspirin and ibuprofen (Advil, Motrin). Consumers are warned that all over-the-counter drugs should be used in strict accordance with label directions and that if an over-the-counter NSAID is needed for more than 10 days, consult a physician.
“We are recommending that patients use some common sense in selecting a medication to treat pain,” Bennett said. “In terms of drug choice, one rule is always best and it holds whether you are treating cancer or treating a headache: use the safest medicine first.”
Medications such as aspirin and acetaminophen (Tylenol) in recommended doses and durations have minimal toxicity, which makes them good first choices, he said. “If those medicines don’t work, try a stronger NSAID such as naproxen (Aleve).”
Bennett noted that low-dose aspirin is recommended to reduce the risk of second heart attacks and that many people having a heart attack are given aspirin to limit heart muscle damage.
Co-authors are Alan Daugherty, Ph.D.; David Herrington, M.D., M.H.S.; Philip Greenland, M.D.; Harold Roberts, M.D., and Kathryn A. Taubert, Ph.D.
Source: AP
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